- Inspector General Act of 1978, as amended, (5 U.S.C. App. 3)
- Health Insurance Portability and Accountability Act of 1996 (HIPAA), establishing the Health Care Fraud and Abuse Control Program, (sections 1128C and 1817(k) of the Social Security Act)
- American Recovery and Reinvestment Act of 2009 (Pub. L. 111-5)
- Patient Protection & Affordable Care Act (Pub. L. 111-148), as amended by the Health Care and Education Reconciliation Act of 2010 (Pub. L. 111-152)
This is not an exhaustive list, but presents the main legislation governing OIG authorities and responsibilities.